| 2. Round | 19/09/2021 | Asteras Tripolis | - | PAOK Saloniki | 0:1 |  |
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| 3. Round | 22/09/2021 | OFI Heraklion | - | Asteras Tripolis | 0:0 | ||||
| 4. Round | 26/09/2021 | Asteras Tripolis | - | Olympiakos Piraeus | 0:2 | ||||
| 6. Round | 16/10/2021 | Apollon Smyrnis | - | Asteras Tripolis | 0:1 | ||||
| 7. Round | 23/10/2021 | Asteras Tripolis | - | Panathinaikos | 2:1 | ||||
| 8. Round | 31/10/2021 | PAS Giannina | - | Asteras Tripolis | 1:1 | |
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| 9. Round | 07/11/2021 | Asteras Tripolis | - | Lamia | 0:1 | ||||
| 21. Round | 02/02/2022 | Asteras Tripolis | - | PAS Giannina | 2:0 |
Spain