1. Round | 11/01/2022 | Club Tijuana [Women] | - | Santos Laguna [Women] | 2:1 | ||||
2. Round | 20/01/2022 | Santos Laguna [Women] | - | Club Necaxa [Women] | 1:1 | ||||
3. Round | 22/01/2022 | Atlas Guadalajara [Women] | - | Santos Laguna [Women] | 1:0 | ||||
4. Round | 28/01/2022 | Santos Laguna [Women] | - | Deportivo Toluca [Women] | 1:0 | ||||
5. Round | 01/02/2022 | Pumas UNAM [Women] | - | Santos Laguna [Women] | 4:0 | ||||
6. Round | 08/02/2022 | Santos Laguna [Women] | - | Club León [Women] | 1:3 | ||||
7. Round | 13/02/2022 | Deportivo Guadalajara [Women] | - | Santos Laguna [Women] | 1:0 | ||||
11. Round | 18/03/2022 | Santos Laguna [Women] | - | CF Pachuca [Women] | 0:1 | ||||
12. Round | 20/03/2022 | Atlético San Luis [Women] | - | Santos Laguna [Women] | 2:4 | ||||
13. Round | 27/03/2022 | CF Monterrey [Women] | - | Santos Laguna [Women] | 3:1 | ||||
14. Round | 01/04/2022 | Santos Laguna [Women] | - | Puebla FC [Women] | 0:0 | ||||
15. Round | 19/04/2022 | UANL Tigres [Women] | - | Santos Laguna [Women] | 4:1 | ||||
16. Round | 26/04/2022 | Santos Laguna [Women] | - | FC Juárez [Women] | 3:1 | ||||
17. Round | 03/05/2022 | Santos Laguna [Women] | - | Mazatlán FC [Women] | 1:0 |