| 1. Round | 04/09/2021 | Atlético Madrid [Women] | - | Rayo Vallecano [Women] | 5:0 | ||||
| 3. Round | 25/09/2021 | Madrid CFF [Women] | - | Rayo Vallecano [Women] | 4:2 | ||||
| 4. Round | 29/09/2021 | Rayo Vallecano [Women] | - | Sporting de Huelva [Women] | 0:0 | ||||
| 8. Round | 31/10/2021 | Rayo Vallecano [Women] | - | Sevilla FC [Women] | 1:0 | ||||
| 15. Round | 09/02/2022 | Levante UD [Women] | - | Rayo Vallecano [Women] | 4:2 | ||||
| 22. Round | 13/02/2022 | Rayo Vallecano [Women] | - | Madrid CFF [Women] | 3:2 | ||||
| 23. Round | 06/03/2022 | Sporting de Huelva [Women] | - | Rayo Vallecano [Women] | 1:1 | ||||
| 24. Round | 13/03/2022 | Rayo Vallecano [Women] | - | Atlético Madrid [Women] | 0:0 | ||||
| 27. Round | 17/04/2022 | Rayo Vallecano [Women] | - | Levante UD [Women] | 3:4 | ||||
| 18. Round | 20/04/2022 | Rayo Vallecano [Women] | - | Real Madrid [Women] | 0:1 | ||||
| 28. Round | 01/05/2022 | Real Sociedad [Women] | - | Rayo Vallecano [Women] | 4:0 | ||||
| 30. Round | 14/05/2022 | Real Betis [Women] | - | Rayo Vallecano [Women] | 1:3 |
USA