| 3. Round | 21/08/2021 | Canet Roussillon | - | Le Puy Foot 43 | 1:0 | ||||
| 4. Round | 28/08/2021 | Angers SCO B | - | Canet Roussillon | 2:0 | ||||
| 5. Round | 04/09/2021 | Canet Roussillon | - | Vendée Les Herbiers | 2:1 | ||||
| 6. Round | 11/09/2021 | Montpellier HSC B | - | Canet Roussillon | 0:0 | ||||
| 7. Round | 18/09/2021 | Canet Roussillon | - | FC Chamalières | 2:0 | ||||
| 9. Round | 09/10/2021 | Canet Roussillon | - | US Colomiers | 1:0 | ||||
| 10. Round | 23/10/2021 | FC Nantes B | - | Canet Roussillon | 1:2 | ||||
| 11. Round | 06/11/2021 | Canet Roussillon | - | Bergerac Périgord FC | 0:3 | ||||
| 12. Round | 20/11/2021 | Canet Roussillon | - | Angoulême CFC | 0:0 | ||||
| 13. Round | 04/12/2021 | Trélissac FC | - | Canet Roussillon | 0:1 | ||||
| 14. Round | 11/12/2021 | Canet Roussillon | - | Moulins Yzeure Foot | 1:2 | ||||
| 18. Round | 12/02/2022 | Canet Roussillon | - | Angers SCO B | 2:0 | ||||
| 20. Round | 05/03/2022 | Canet Roussillon | - | Montpellier HSC B | 0:1 |  |
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| 27. Round | 30/04/2022 | Canet Roussillon | - | Trélissac FC | 1:2 | ||||
| 29. Round | 21/05/2022 | Canet Roussillon | - | AS Béziers | 4:1 | ||||
| 30. Round | 28/05/2022 | Stade Montois | - | Canet Roussillon | 2:2 |
Senegal