| 2. Round | 04/09/2021 | Rayo Majadahonda | - | CD Calahorra | 2:1 | ||||
| 3. Round | 11/09/2021 | CD Calahorra | - | Deportivo La Coruña | 0:3 | ||||
| 7. Round | 09/10/2021 | Racing Santander | - | CD Calahorra | 1:0 | ||||
| 8. Round | 15/10/2021 | CD Calahorra | - | Real Unión | 2:4 | ||||
| 11. Round | 06/11/2021 | Real Valladolid B | - | CD Calahorra | 1:1 | ||||
| 15. Round | 04/12/2021 | SD Logroñés | - | CD Calahorra | 0:0 |
Spain