| 1. Round | 05/09/2021 | CS Puertollano CF | - | CA Pulpileño | 2:0 |  |
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| 2. Round | 12/09/2021 | Atlético Mancha Real | - | CS Puertollano CF | 2:0 | ||||
| 3. Round | 19/09/2021 | CS Puertollano CF | - | Levante UD B | 0:0 | |
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| 4. Round | 26/09/2021 | CD Toledo | - | CS Puertollano CF | 1:4 | ||||
| 6. Round | 10/10/2021 | CD Marchamalo | - | CS Puertollano CF | 0:0 | ||||
| 11. Round | 14/11/2021 | CS Puertollano CF | - | Hércules CF | 2:1 | ||||
| 12. Round | 21/11/2021 | Mar Menor CF | - | CS Puertollano CF | 1:0 | ||||
| 13. Round | 28/11/2021 | CS Puertollano CF | - | Real Murcia | 1:2 | ||||
| 14. Round | 05/12/2021 | UD Alzira | - | CS Puertollano CF | 2:1 |
Spain