| 2. Round | 14/08/2010 | AC Arles-Avignon | - | RC Lens | 0:1 |  |
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| 3. Round | 21/08/2010 | RC Lens | - | AS Monaco | 2:2 | ||||
| 5. Round | 11/09/2010 | RC Lens | - | Lille OSC | 1:4 | ||||
| 6. Round | 18/09/2010 | Valenciennes FC | - | RC Lens | 1:1 | ||||
| 7. Round | 26/09/2010 | RC Lens | - | Paris Saint-Germain | 0:2 |  |
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| 9. Round | 17/10/2010 | RC Lens | - | Stade Rennais | 0:0 | ||||
| 10. Round | 23/10/2010 | RC Lens | - | OGC Nice | 1:0 | ||||
| 30. Round | 10/04/2011 | Olympique Lyonnais | - | RC Lens | 3:0 | ||||
| 31. Round | 16/04/2011 | RC Lens | - | Stade Brestois 29 | 1:1 | ||||
| 32. Round | 24/04/2011 | AJ Auxerre | - | RC Lens | 1:1 | ||||
| 33. Round | 30/04/2011 | RC Lens | - | FC Lorient | 2:3 | ||||
| 34. Round | 07/05/2011 | SM Caen | - | RC Lens | 1:1 | ||||
| 35. Round | 11/05/2011 | RC Lens | - | Girondins Bordeaux | 1:0 | ||||
| 36. Round | 15/05/2011 | AS Monaco | - | RC Lens | 1:1 | ||||
| 37. Round | 21/05/2011 | RC Lens | - | AC Arles-Avignon | 0:1 | ||||
| 38. Round | 29/05/2011 | AS Nancy Lorraine | - | RC Lens | 4:0 |
France