| 1. Round | 04/09/2021 | Hércules CF | - | Recreativo Granada | 1:1 |  |
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| 2. Round | 12/09/2021 | CF Intercity | - | Hércules CF | 1:2 | ||||
| 6. Round | 10/10/2021 | CA Pulpileño | - | Hércules CF | 0:4 | |
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| 8. Round | 24/10/2021 | CD El Ejido 2012 | - | Hércules CF | 0:1 | ||||
| 9. Round | 31/10/2021 | Hércules CF | - | CF La Nucía | 0:0 | ||||
| 11. Round | 14/11/2021 | CS Puertollano CF | - | Hércules CF | 2:1 | ||||
| 12. Round | 21/11/2021 | Hércules CF | - | Real Murcia | 3:0 | ||||
| 13. Round | 28/11/2021 | UD Melilla | - | Hércules CF | 1:2 | ||||
| 15. Round | 12/12/2021 | Atlético Mancha Real | - | Hércules CF | 1:2 | |
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| 17. Round | 09/01/2022 | CD Marchamalo | - | Hércules CF | 0:1 |
Spain