| 1. Round | 10/01/2021 | Atlético San Luis [Women] | - | CF Monterrey [Women] | 0:5 | ||||
| 2. Round | 15/01/2021 | Gallos Blancos [Women] | - | Atlético San Luis [Women] | 3:2 | ||||
| 7. Round | 14/02/2021 | Atlético San Luis [Women] | - | Mazatlán FC [Women] | 3:0 | ||||
| 9. Round | 07/03/2021 | Atlético San Luis [Women] | - | CF América [Women] | 1:0 | ||||
| 12. Round | 21/03/2021 | Atlético San Luis [Women] | - | Santos Laguna [Women] | 2:2 | ||||
| 16. Round | 26/04/2021 | Atlético San Luis [Women] | - | Deportivo Toluca [Women] | 1:2 | ||||
| 17. Round | 01/05/2021 | CF Pachuca [Women] | - | Atlético San Luis [Women] | 4:1 |  |
Mexico