| 1. Round | 07/08/2022 | Angers SCO | - | FC Nantes | 0:0 | ||||
| 2. Round | 12/08/2022 | FC Nantes | - | Lille OSC | 1:1 | ||||
| 3. Round | 20/08/2022 | Olympique Marseille | - | FC Nantes | 2:1 | ||||
| 4. Round | 28/08/2022 | FC Nantes | - | Toulouse FC | 3:1 | ||||
| 5. Round | 31/08/2022 | RC Strasbourg | - | FC Nantes | 1:1 | ||||
| 6. Round | 03/09/2022 | FC Nantes | - | Paris Saint-Germain | 0:3 | ||||
| 7. Round | 11/09/2022 | FC Lorient | - | FC Nantes | 3:2 |  |
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| 8. Round | 18/09/2022 | FC Nantes | - | RC Lens | 0:0 | ||||
| 9. Round | 02/10/2022 | AS Monaco | - | FC Nantes | 4:1 | ||||
| 10. Round | 09/10/2022 | Stade Rennais | - | FC Nantes | 3:0 | ||||
| 11. Round | 16/10/2022 | FC Nantes | - | Stade Brestois 29 | 4:1 | ||||
| 12. Round | 23/10/2022 | OGC Nice | - | FC Nantes | 1:1 | ||||
| 13. Round | 30/10/2022 | FC Nantes | - | Clermont Foot 63 | 1:1 | ||||
| 14. Round | 06/11/2022 | Stade de Reims | - | FC Nantes | 1:0 | ||||
| 15. Round | 13/11/2022 | FC Nantes | - | AC Ajaccio | 2:2 |
France
Ghana