| 1. Round | 07/08/2021 | RC Lens B | - | FC Fleury 91 | 1:3 |  |
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| 2. Round | 14/08/2021 | US Lusitanos | - | RC Lens B | 2:0 | ||||
| 7. Round | 18/09/2021 | RC Lens B | - | ASM Belfort | 1:1 | ||||
| 8. Round | 25/09/2021 | Sainte-Geneviève-des-Bois | - | RC Lens B | 1:1 | ||||
| 9. Round | 09/10/2021 | RC Lens B | - | Stade de Reims B | 2:5 | ||||
| 12. Round | 20/11/2021 | Paris 13 Atletico | - | RC Lens B | 0:0 | ||||
| 15. Round | 15/01/2022 | AS Beauvais | - | RC Lens B | 2:1 | ||||
| 21. Round | 12/03/2022 | ASM Belfort | - | RC Lens B | 1:1 | ||||
| 22. Round | 19/03/2022 | RC Lens B | - | Sainte-Geneviève-des-Bois | 0:0 | ||||
| 23. Round | 26/03/2022 | Stade de Reims B | - | RC Lens B | 0:3 | ||||
| 24. Round | 09/04/2022 | RC Lens B | - | AJ Auxerre B | 0:1 | |
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| 25. Round | 16/04/2022 | FCSR Haguenau | - | RC Lens B | 0:1 | |
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| 28. Round | 14/05/2022 | RC Lens B | - | Olympique Saint-Quentin | 1:2 | |
Guadeloupe