| 1. Round | 20/08/2022 | PAOK Saloniki | - | Panetolikos | 1:0 | ||||
| 2. Round | 28/08/2022 | Panetolikos | - | Aris Saloniki | 3:1 | ||||
| 3. Round | 04/09/2022 | Atromitos | - | Panetolikos | 1:1 | ||||
| 4. Round | 10/09/2022 | OFI Heraklion | - | Panetolikos | 1:2 | ||||
| 5. Round | 17/09/2022 | Panetolikos | - | AEK Athen | 0:2 | ||||
| 6. Round | 03/10/2022 | PAS Giannina | - | Panetolikos | 1:4 | ||||
| 7. Round | 08/10/2022 | Panetolikos | - | Volos NFC | 2:3 | ||||
| 8. Round | 16/10/2022 | Asteras Tripolis | - | Panetolikos | 0:0 | ||||
| 9. Round | 22/10/2022 | Panetolikos | - | Olympiakos Piraeus | 0:2 | ||||
| 10. Round | 29/10/2022 | Ionikos Nikea | - | Panetolikos | 1:1 | ||||
| 11. Round | 06/11/2022 | Panetolikos | - | Levadiakos | 0:0 | ||||
| 12. Round | 09/11/2022 | Panetolikos | - | Panathinaikos | 0:1 | ||||
| 13. Round | 13/11/2022 | Lamia | - | Panetolikos | 1:3 |  |
Canada
Jamaica 