| 1. Round | 11/01/2021 | Club León [Women] | - | Deportivo Toluca [Women] | 0:2 | ||||
| 5. Round | 04/02/2021 | Deportivo Toluca [Women] | - | Puebla FC [Women] | 2:1 | ||||
| 6. Round | 09/02/2021 | CF Pachuca [Women] | - | Deportivo Toluca [Women] | 2:0 | ||||
| 7. Round | 15/02/2021 | Deportivo Toluca [Women] | - | Cruz Azul [Women] | 1:1 | ||||
| 11. Round | 14/03/2021 | CF Monterrey [Women] | - | Deportivo Toluca [Women] | 1:0 | ||||
| 12. Round | 22/03/2021 | Deportivo Toluca [Women] | - | Club Necaxa [Women] | 1:1 | ||||
| 13. Round | 27/03/2021 | Atlas Guadalajara [Women] | - | Deportivo Toluca [Women] | 1:2 | ||||
| 16. Round | 26/04/2021 | Atlético San Luis [Women] | - | Deportivo Toluca [Women] | 1:2 |  |
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| 17. Round | 03/05/2021 | Deportivo Toluca [Women] | - | Pumas UNAM [Women] | 0:1 |
Mexico