| 1. Round | 29/07/2021 | TM Fútbol Club | - | Leones Negros | 3:2 | ||||
| 2. Round | 03/08/2021 | Club Celaya | - | TM Fútbol Club | 0:0 | ||||
| 3. Round | 11/08/2021 | TM Fútbol Club | - | Venados FC | 3:0 | ||||
| 5. Round | 25/08/2021 | TM Fútbol Club | - | Tapatío | 1:1 | ||||
| 6. Round | 31/08/2021 | Mineros de Zacatecas | - | TM Fútbol Club | 1:2 | ||||
| 7. Round | 08/09/2021 | CF Monterrey II | - | TM Fútbol Club | 0:0 | ||||
| 8. Round | 15/09/2021 | TM Fútbol Club | - | Coyotes de Tlaxcala | 0:2 | ||||
| 9. Round | 23/09/2021 | TM Fútbol Club | - | Cimarrones de Sonora | 1:2 | ||||
| 10. Round | 30/09/2021 | Cancún FC | - | TM Fútbol Club | 1:1 | ||||
| 13. Round | 21/10/2021 | TM Fútbol Club | - | Atlante | 1:1 |  |
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| 14. Round | 28/10/2021 | Tepatitlán | - | TM Fútbol Club | 1:1 | ||||
| 15. Round | 04/11/2021 | TM Fútbol Club | - | Atlético Morelia | 1:1 | ||||
| 16. Round | 10/11/2021 | Dorados de Sinaloa | - | TM Fútbol Club | 0:3 | |
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| 17. Round | 17/11/2021 | TM Fútbol Club | - | Pumas Tabasco | 1:1 |
Mexico