| 1. Round | 13/02/2022 | SL Benfica [Youth] | - | FC Porto [Youth] | 1:0 | ||||
| 2. Round | 20/02/2022 | GD Estoril [Youth] | - | SL Benfica [Youth] | 1:4 | ||||
| 3. Round | 25/02/2022 | Sporting CP [Youth] | - | SL Benfica [Youth] | 0:1 |  |
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| 4. Round | 06/03/2022 | SL Benfica [Youth] | - | Vitória Guimarães [Youth] | 4:1 | ||||
| 5. Round | 13/03/2022 | Rio Ave FC [Youth] | - | SL Benfica [Youth] | 3:3 | ||||
| 6. Round | 02/04/2022 | SL Benfica [Youth] | - | FC Alverca [Youth] | 3:1 | ||||
| 7. Round | 08/04/2022 | Sporting Braga [Youth] | - | SL Benfica [Youth] | 1:1 | ||||
| 8. Round | 17/04/2022 | FC Porto [Youth] | - | SL Benfica [Youth] | 3:2 | ||||
| 10. Round | 01/05/2022 | SL Benfica [Youth] | - | Sporting CP [Youth] | 2:2 | ||||
| 11. Round | 07/05/2022 | Vitória Guimarães [Youth] | - | SL Benfica [Youth] | 0:2 |  |
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| 9. Round | 17/05/2022 | SL Benfica [Youth] | - | GD Estoril [Youth] | 3:1 | |
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| 13. Round | 21/05/2022 | FC Alverca [Youth] | - | SL Benfica [Youth] | 1:2 | ||||
| 14. Round | 28/05/2022 | SL Benfica [Youth] | - | Sporting Braga [Youth] | 3:0 |
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