| 1. Round | 05/09/2021 | CD El Ejido 2012 | - | UD Alzira | 1:1 |  |
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| 2. Round | 12/09/2021 | UD Socuéllamos | - | CD El Ejido 2012 | 1:3 | ||||
| 3. Round | 19/09/2021 | CD El Ejido 2012 | - | CA Pulpileño | 0:1 | ||||
| 4. Round | 25/09/2021 | Levante UD B | - | CD El Ejido 2012 | 0:0 | |
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| 5. Round | 03/10/2021 | CS Puertollano CF | - | CD El Ejido 2012 | 1:1 | ||||
| 6. Round | 10/10/2021 | CD El Ejido 2012 | - | CF La Nucía | 0:2 | ||||
| 9. Round | 31/10/2021 | Real Murcia | - | CD El Ejido 2012 | 1:1 | |
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| 11. Round | 14/11/2021 | Águilas FC | - | CD El Ejido 2012 | 0:1 | |
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| 12. Round | 21/11/2021 | CD El Ejido 2012 | - | Atlético Mancha Real | 0:1 | ||||
| 13. Round | 28/11/2021 | CD Toledo | - | CD El Ejido 2012 | 0:1 | ||||
| 14. Round | 05/12/2021 | CD El Ejido 2012 | - | CD Marchamalo | 2:2 | ||||
| 15. Round | 12/12/2021 | Recreativo Granada | - | CD El Ejido 2012 | 0:1 | ||||
| 16. Round | 19/12/2021 | CD El Ejido 2012 | - | CF Intercity | 0:1 | ||||
| 17. Round | 16/01/2022 | Mar Menor CF | - | CD El Ejido 2012 | 1:0 | ||||
| 18. Round | 23/01/2022 | UD Alzira | - | CD El Ejido 2012 | 2:0 |
Spain