| 1. Round | 08/08/2021 | Montpellier HSC | - | Olympique Marseille | 2:3 | ||||
| 2. Round | 15/08/2021 | Stade de Reims | - | Montpellier HSC | 3:3 | ||||
| 3. Round | 22/08/2021 | Montpellier HSC | - | FC Lorient | 3:1 | ||||
| 4. Round | 29/08/2021 | Lille OSC | - | Montpellier HSC | 2:1 | ||||
| 5. Round | 12/09/2021 | Montpellier HSC | - | AS Saint-Étienne | 2:0 | ||||
| 23. Round | 05/02/2022 | AS Saint-Étienne | - | Montpellier HSC | 3:1 | ||||
| 31. Round | 10/04/2022 | Olympique Marseille | - | Montpellier HSC | 2:0 | ||||
| 32. Round | 17/04/2022 | Montpellier HSC | - | Stade de Reims | 0:0 | ||||
| 35. Round | 01/05/2022 | Montpellier HSC | - | FC Metz | 2:2 | ||||
| 36. Round | 08/05/2022 | Clermont Foot 63 | - | Montpellier HSC | 2:1 | ||||
| 37. Round | 14/05/2022 | Montpellier HSC | - | Paris Saint-Germain | 0:4 |
France
Congo DR