| 2. Round | 29/08/2021 | St-Pryvé St-Hilaire [Youth] | - | Lille OSC [Youth] | 1:2 | ||||
| 3. Round | 05/09/2021 | Lille OSC [Youth] | - | Évreux FC 27 [Youth] | 3:2 | ||||
| 4. Round | 11/09/2021 | Lille OSC [Youth] | - | Entente Feignies Aulnoye [Youth] | 3:1 | ||||
| 6. Round | 26/09/2021 | Lille OSC [Youth] | - | JA Drancy [Youth] | 0:1 | ||||
| 8. Round | 10/10/2021 | Lille OSC [Youth] | - | Havre AC [Youth] | 1:1 | ||||
| 11. Round | 14/11/2021 | Valenciennes FC [Youth] | - | Lille OSC [Youth] | 2:1 | ||||
| 12. Round | 20/11/2021 | Lille OSC [Youth] | - | US Orléans [Youth] | 1:4 | ||||
| 14. Round | 05/12/2021 | Lille OSC [Youth] | - | St-Pryvé St-Hilaire [Youth] | 6:0 |  |
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| 20. Round | 20/03/2022 | Havre AC [Youth] | - | Lille OSC [Youth] | 4:2 | ||||
| 25. Round | 01/05/2022 | Lille OSC [Youth] | - | RC Lens [Youth] | 2:0 |
France