| 8. Round | 25/09/2021 | US Colomiers | - | FC Nantes B | 0:2 | ||||
| 12. Round | 20/11/2021 | US Colomiers | - | Moulins Yzeure Foot | 0:1 | ||||
| 18. Round | 12/02/2022 | US Colomiers | - | Montpellier HSC B | 1:1 | ||||
| 22. Round | 19/03/2022 | FC Nantes B | - | US Colomiers | 2:1 | ||||
| 30. Round | 28/05/2022 | Le Puy Foot 43 | - | US Colomiers | 2:1 |
France