| 9. Round | 01/10/2022 | Southampton FC | - | Everton FC | 1:2 | ||||
| 11. Round | 16/10/2022 | Southampton FC | - | West Ham United | 1:1 | ||||
| 12. Round | 19/10/2022 | AFC Bournemouth | - | Southampton FC | 0:1 | ||||
| 13. Round | 23/10/2022 | Southampton FC | - | Arsenal FC | 1:1 | ||||
| 14. Round | 29/10/2022 | Crystal Palace | - | Southampton FC | 1:0 | ||||
| 15. Round | 06/11/2022 | Southampton FC | - | Newcastle United | 1:4 | ||||
| 16. Round | 12/11/2022 | Liverpool FC | - | Southampton FC | 3:1 |  |
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| 19. Round | 04/01/2023 | Southampton FC | - | Nottingham Forest | 0:1 | ||||
| 20. Round | 14/01/2023 | Everton FC | - | Southampton FC | 1:2 | ||||
| 21. Round | 21/01/2023 | Southampton FC | - | Aston Villa | 0:1 | ||||
| 29. Round | 02/04/2023 | West Ham United | - | Southampton FC | 1:0 | |
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| 32. Round | 21/04/2023 | Arsenal FC | - | Southampton FC | 3:3 |  |
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| 33. Round | 27/04/2023 | Southampton FC | - | AFC Bournemouth | 0:1 |
Croatia