| 1. Round | 29/08/2021 | Toulouse FC [Youth B] | - | Nîmes Olympique [Youth B] | 3:0 | ||||
| 2. Round | 05/09/2021 | Nîmes Olympique [Youth B] | - | Pau FC [Youth B] | 2:2 | ||||
| 3. Round | 11/09/2021 | FC Istres [Youth B] | - | Nîmes Olympique [Youth B] | 3:3 | ||||
| 4. Round | 18/09/2021 | Nîmes Olympique [Youth B] | - | Marignane Gignac [Youth B] | 3:4 |  |
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| 5. Round | 26/09/2021 | SA Mérignac [Youth B] | - | Nîmes Olympique [Youth B] | 2:2 | ||||
| 7. Round | 09/10/2021 | AC Vedène [Youth B] | - | Nîmes Olympique [Youth B] | 0:4 | |
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| 8. Round | 17/10/2021 | AS Béziers [Youth B] | - | Nîmes Olympique [Youth B] | 1:0 |  |
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| 9. Round | 23/10/2021 | Nîmes Olympique [Youth B] | - | Montpellier HSC [Youth B] | 0:4 | ||||
| 14. Round | 16/01/2022 | Pau FC [Youth B] | - | Nîmes Olympique [Youth B] | 3:2 | |
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| 15. Round | 30/01/2022 | Nîmes Olympique [Youth B] | - | FC Istres [Youth B] | 1:1 | ||||
| 20. Round | 20/03/2022 | Nîmes Olympique [Youth B] | - | AS Béziers [Youth B] | 1:1 | ||||
| 24. Round | 17/04/2022 | Nîmes Olympique [Youth B] | - | Montauban FC [Youth B] | 3:1 | ||||
| 26. Round | 15/05/2022 | Nîmes Olympique [Youth B] | - | Toulouse FC [Youth B] | 1:1 |
France