| 2. Round | 14/08/2021 | AS Vitré | - | EA Guingamp B | 0:4 | ||||
| 5. Round | 04/09/2021 | EA Guingamp B | - | Stade Plabennec | 2:1 |  |
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| 7. Round | 18/09/2021 | EA Guingamp B | - | Blois Foot 41 | 2:3 | ||||
| 9. Round | 09/10/2021 | EA Guingamp B | - | SM Caen B | 1:1 |  |
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| 10. Round | 23/10/2021 | EA Guingamp B | - | AS Poissy | 1:1 | ||||
| 11. Round | 06/11/2021 | C'Chartres Football | - | EA Guingamp B | 1:2 | ||||
| 15. Round | 15/01/2022 | SO Romorantin | - | EA Guingamp B | 2:3 | ||||
| 16. Round | 22/01/2022 | EA Guingamp B | - | AS Vitré | 0:5 | ||||
| 13. Round | 26/01/2022 | Vannes OC | - | EA Guingamp B | 2:0 | ||||
| 21. Round | 12/03/2022 | Blois Foot 41 | - | EA Guingamp B | 5:2 | ||||
| 24. Round | 09/04/2022 | AS Poissy | - | EA Guingamp B | 1:1 | ||||
| 25. Round | 16/04/2022 | EA Guingamp B | - | C'Chartres Football | 3:4 | |
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| 26. Round | 23/04/2022 | Châteaubriant Voltigeurs | - | EA Guingamp B | 0:2 | ||||
| 27. Round | 30/04/2022 | EA Guingamp B | - | Vannes OC | 1:0 | ||||
| 28. Round | 14/05/2022 | US Granvillaise | - | EA Guingamp B | 3:4 | ||||
| 29. Round | 21/05/2022 | EA Guingamp B | - | SO Romorantin | 1:2 | ||||
| 30. Round | 28/05/2022 | FC Rouen 1899 | - | EA Guingamp B | 2:1 |
France