| 8. Round | 17/10/2021 | AS Béziers [Youth B] | - | Nîmes Olympique [Youth B] | 1:0 | ||||
| 9. Round | 23/10/2021 | Nîmes Olympique [Youth B] | - | Montpellier HSC [Youth B] | 0:4 | ||||
| 10. Round | 14/11/2021 | Rodez AF [Youth B] | - | Nîmes Olympique [Youth B] | 1:2 | ||||
| 11. Round | 21/11/2021 | Nîmes Olympique [Youth B] | - | Girondins Bordeaux [Youth B] | 0:0 | ||||
| 12. Round | 28/11/2021 | Montauban FC [Youth B] | - | Nîmes Olympique [Youth B] | 2:3 | ||||
| 13. Round | 05/12/2021 | Nîmes Olympique [Youth B] | - | Balma SC [Youth B] | 1:3 | ||||
| 19. Round | 13/03/2022 | Nîmes Olympique [Youth B] | - | AC Vedène [Youth B] | 3:1 | ||||
| 20. Round | 20/03/2022 | Nîmes Olympique [Youth B] | - | AS Béziers [Youth B] | 1:1 | ||||
| 21. Round | 27/03/2022 | Montpellier HSC [Youth B] | - | Nîmes Olympique [Youth B] | 1:3 | ||||
| 23. Round | 10/04/2022 | Girondins Bordeaux [Youth B] | - | Nîmes Olympique [Youth B] | 5:1 |
France