| 2. Round | 14/08/2021 | Étoile FC | - | Jura Sud | 1:2 | ||||
| 3. Round | 21/08/2021 | Jura Sud | - | GOAL FC | 2:1 | ||||
| 4. Round | 28/08/2021 | Aubagne FC | - | Jura Sud | 2:1 | ||||
| 5. Round | 04/09/2021 | Jura Sud | - | SC Toulon | 0:0 | ||||
| 6. Round | 11/09/2021 | Jura Sud | - | Olympique Marseille B | 0:1 | ||||
| 7. Round | 18/09/2021 | Marignane Gignac FC | - | Jura Sud | 1:0 | ||||
| 8. Round | 25/09/2021 | Jura Sud | - | Olympique Lyonnais B | 1:1 |  |
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| 9. Round | 09/10/2021 | RC Grasse | - | Jura Sud | 1:4 | ||||
| 10. Round | 23/10/2021 | Jura Sud | - | Louhans-Cuiseaux | 1:1 |  |
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| 11. Round | 06/11/2021 | Hyères FC | - | Jura Sud | 2:2 | ||||
| 13. Round | 04/12/2021 | AS Monaco B | - | Jura Sud | 1:1 | |
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| 14. Round | 11/12/2021 | Jura Sud | - | FC Martigues | 1:4 | ||||
| 16. Round | 22/01/2022 | Jura Sud | - | Étoile FC | 1:0 | |
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| 1. Round | 26/01/2022 | Jura Sud | - | AS Saint-Priest | 2:0 | |
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| 15. Round | 29/01/2022 | GFA Rumilly Vallières | - | Jura Sud | 1:2 | |
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| 18. Round | 12/02/2022 | Jura Sud | - | Aubagne FC | 1:0 | ||||
| 19. Round | 19/02/2022 | SC Toulon | - | Jura Sud | 2:1 | |
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| 20. Round | 05/03/2022 | Olympique Marseille B | - | Jura Sud | 3:0 | ||||
| 21. Round | 12/03/2022 | Jura Sud | - | Marignane Gignac FC | 2:0 | |
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Mayotte
France