| 1. Round | 12/02/2022 | Banfield II | - | San Lorenzo II | 2:1 | ||||
| 3. Round | 21/02/2022 | San Lorenzo II | - | Defensa y Justicia II | 0:4 | ||||
| 4. Round | 26/02/2022 | Argentinos Juniors II | - | San Lorenzo II | 2:0 | ||||
| 6. Round | 12/03/2022 | Talleres de Córdoba II | - | San Lorenzo II | 2:3 | ||||
| 7. Round | 21/03/2022 | San Lorenzo II | - | Huracán II | 0:0 | ||||
| 9. Round | 10/04/2022 | Sarmiento de Junín II | - | San Lorenzo II | 1:2 | ||||
| 10. Round | 15/04/2022 | San Lorenzo II | - | Platense II | 1:1 | ||||
| 11. Round | 20/04/2022 | Unión de Santa Fe II | - | San Lorenzo II | 1:4 | ||||
| 12. Round | 24/04/2022 | San Lorenzo II | - | Patronato de Paraná II | 3:0 | ||||
| 13. Round | 30/04/2022 | Newell's Old Boys II | - | San Lorenzo II | 0:3 | ||||
| 14. Round | 09/05/2022 | San Lorenzo II | - | Racing Club II | 3:1 |
Argentina