| 1. Round | 05/06/2022 | Independiente II | - | San Lorenzo II | 0:1 | ||||
| 2. Round | 09/06/2022 | San Lorenzo II | - | Newell's Old Boys II | 2:3 | ||||
| 3. Round | 14/06/2022 | Arsenal de Sarandí II | - | San Lorenzo II | 0:1 |  |
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| 4. Round | 20/06/2022 | San Lorenzo II | - | Central Córdoba SdE II | 0:0 | ||||
| 5. Round | 25/06/2022 | Tigre II | - | San Lorenzo II | 3:2 | ||||
| 6. Round | 03/07/2022 | San Lorenzo II | - | Barracas Central II | 1:0 | ||||
| 16. Round | 28/08/2022 | Rosario Central II | - | San Lorenzo II | 0:1 |  |
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| 18. Round | 07/09/2022 | Atlético Tucumán II | - | San Lorenzo II | 1:2 | ||||
| 20. Round | 19/09/2022 | River Plate II | - | San Lorenzo II | 1:0 | ||||
| 21. Round | 25/09/2022 | San Lorenzo II | - | Lanús II | 1:2 |
Argentina