| 2. Round | 16/02/2022 | Gimnasia de La Plata II | - | San Lorenzo II | 2:1 | ||||
| 4. Round | 26/02/2022 | Argentinos Juniors II | - | San Lorenzo II | 2:0 | ||||
| 5. Round | 04/03/2022 | San Lorenzo II | - | River Plate II | 0:4 | ||||
| 10. Round | 15/04/2022 | San Lorenzo II | - | Platense II | 1:1 | ||||
| 12. Round | 24/04/2022 | San Lorenzo II | - | Patronato de Paraná II | 3:0 | ||||
| 13. Round | 30/04/2022 | Newell's Old Boys II | - | San Lorenzo II | 0:3 | ||||
| 14. Round | 09/05/2022 | San Lorenzo II | - | Racing Club II | 3:1 |
Argentina