| 1. Round | 05/09/2021 | CS Puertollano CF | - | CA Pulpileño | 2:0 | ||||
| 2. Round | 12/09/2021 | CA Pulpileño | - | Levante UD B | 1:0 | ||||
| 3. Round | 19/09/2021 | CD El Ejido 2012 | - | CA Pulpileño | 0:1 | ||||
| 4. Round | 26/09/2021 | CA Pulpileño | - | CF La Nucía | 1:4 | ||||
| 5. Round | 03/10/2021 | CD Eldense | - | CA Pulpileño | 0:3 | ||||
| 7. Round | 17/10/2021 | Real Murcia | - | CA Pulpileño | 1:1 |  |
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| 8. Round | 24/10/2021 | CA Pulpileño | - | UD Melilla | 1:3 | ||||
| 9. Round | 31/10/2021 | Águilas FC | - | CA Pulpileño | 0:0 | ||||
| 10. Round | 07/11/2021 | CA Pulpileño | - | Atlético Mancha Real | 2:0 | ||||
| 11. Round | 14/11/2021 | CD Toledo | - | CA Pulpileño | 0:1 | ||||
| 12. Round | 21/11/2021 | CA Pulpileño | - | CD Marchamalo | 1:1 | ||||
| 13. Round | 28/11/2021 | Recreativo Granada | - | CA Pulpileño | 1:1 | |
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| 14. Round | 05/12/2021 | CA Pulpileño | - | CF Intercity | 1:1 | ||||
| 15. Round | 12/12/2021 | Mar Menor CF | - | CA Pulpileño | 4:0 | |
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| 16. Round | 19/12/2021 | CA Pulpileño | - | UD Alzira | 1:1 | ||||
| 17. Round | 09/01/2022 | UD Socuéllamos | - | CA Pulpileño | 1:0 | ||||
| 19. Round | 30/01/2022 | Levante UD B | - | CA Pulpileño | 0:1 |  |
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| 20. Round | 06/02/2022 | CA Pulpileño | - | CD El Ejido 2012 | 0:1 |
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