| 1. Round | 07/08/2021 | Montpellier HSC B | - | Bergerac Périgord FC | 1:1 | ||||
| 2. Round | 14/08/2021 | Montpellier HSC B | - | FC Chamalières | 1:2 | ||||
| 5. Round | 02/09/2021 | FC Nantes B | - | Montpellier HSC B | 1:0 | ||||
| 6. Round | 11/09/2021 | Montpellier HSC B | - | Canet Roussillon | 0:0 | ||||
| 7. Round | 17/09/2021 | Angoulême CFC | - | Montpellier HSC B | 3:2 |  |
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| 8. Round | 25/09/2021 | Montpellier HSC B | - | Trélissac FC | 1:2 | ||||
| 9. Round | 09/10/2021 | Moulins Yzeure Foot | - | Montpellier HSC B | 1:2 | ||||
| 10. Round | 23/10/2021 | Montpellier HSC B | - | AS Béziers | 2:0 | ||||
| 11. Round | 06/11/2021 | Stade Montois | - | Montpellier HSC B | 1:2 | ||||
| 12. Round | 20/11/2021 | Montpellier HSC B | - | Bourges Foot 18 | 2:3 | ||||
| 13. Round | 04/12/2021 | Le Puy Foot 43 | - | Montpellier HSC B | 2:0 | ||||
| 14. Round | 11/12/2021 | Montpellier HSC B | - | Angers SCO B | 0:4 | ||||
| 21. Round | 12/03/2022 | Montpellier HSC B | - | Angoulême CFC | 0:0 | ||||
| 22. Round | 19/03/2022 | Trélissac FC | - | Montpellier HSC B | 3:0 | ||||
| 29. Round | 21/05/2022 | Montpellier HSC B | - | Vendée Les Herbiers | 1:0 | ||||
| 30. Round | 28/05/2022 | Bergerac Périgord FC | - | Montpellier HSC B | 2:1 |
France