| 6. Round | 02/10/2021 | Montauban FC [Youth B] | - | Pau FC [Youth B] | 3:2 | ||||
| 7. Round | 10/10/2021 | Pau FC [Youth B] | - | Balma SC [Youth B] | 0:1 | ||||
| 10. Round | 14/11/2021 | Pau FC [Youth B] | - | FC Istres [Youth B] | 4:5 |  |
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| 11. Round | 21/11/2021 | Marignane Gignac [Youth B] | - | Pau FC [Youth B] | 2:1 | ||||
| 12. Round | 28/11/2021 | Pau FC [Youth B] | - | SA Mérignac [Youth B] | 1:1 | ||||
| 13. Round | 05/12/2021 | AS Muret [Youth B] | - | Pau FC [Youth B] | 0:3 | ||||
| 14. Round | 16/01/2022 | Pau FC [Youth B] | - | Nîmes Olympique [Youth B] | 3:2 | ||||
| 16. Round | 06/02/2022 | Pau FC [Youth B] | - | Rodez AF [Youth B] | 0:1 | ||||
| 17. Round | 12/02/2022 | Girondins Bordeaux [Youth B] | - | Pau FC [Youth B] | 2:1 | ||||
| 15. Round | 20/02/2022 | Montpellier HSC [Youth B] | - | Pau FC [Youth B] | 2:1 | ||||
| 18. Round | 06/03/2022 | Pau FC [Youth B] | - | Montauban FC [Youth B] | 4:1 | ||||
| 21. Round | 27/03/2022 | AS Béziers [Youth B] | - | Pau FC [Youth B] | 2:0 | ||||
| 24. Round | 17/04/2022 | SA Mérignac [Youth B] | - | Pau FC [Youth B] | 2:5 | ||||
| 25. Round | 01/05/2022 | Pau FC [Youth B] | - | AS Muret [Youth B] | 4:0 | ||||
| 26. Round | 15/05/2022 | AC Vedène [Youth B] | - | Pau FC [Youth B] | 2:1 |
France