| 1. Round | 11/09/2020 | Arsenal FC U23 | - | Southampton FC U23 | 1:2 | ||||
| 2. Round | 18/09/2020 | Southampton FC U23 | - | Chelsea FC U23 | 1:4 | ||||
| 5. Round | 18/10/2020 | Southampton FC U23 | - | Blackburn Rovers U23 | 0:1 | ||||
| 6. Round | 23/10/2020 | Derby County U23 | - | Southampton FC U23 | 3:1 | ||||
| 8. Round | 07/11/2020 | Southampton FC U23 | - | Manchester City U23 | 5:2 | ||||
| 9. Round | 21/11/2020 | Liverpool FC U23 | - | Southampton FC U23 | 0:0 |
France