| 11. Round | 21/11/2021 | Angers SCO [Youth B] | - | LB Châteauroux [Youth B] | 4:2 | ||||
| 12. Round | 28/11/2021 | SO Cholet [Youth B] | - | Angers SCO [Youth B] | 2:4 | ||||
| 14. Round | 23/02/2022 | Stade brestois 29 [Youth B] | - | Angers SCO [Youth B] | 3:1 | ||||
| 15. Round | 27/02/2022 | Angers SCO [Youth B] | - | Chamois Niortais [Youth B] | 4:0 | ||||
| 18. Round | 06/03/2022 | CPBB Rennes [Youth B] | - | Angers SCO [Youth B] | 0:5 | ||||
| 19. Round | 13/03/2022 | Angers SCO [Youth B] | - | Angoulême CFC [Youth B] | 9:0 | ||||
| 20. Round | 20/03/2022 | Vannes OC [Youth B] | - | Angers SCO [Youth B] | 0:2 | ||||
| 21. Round | 27/03/2022 | Angers SCO [Youth B] | - | FC Nantes [Youth B] | 1:1 | ||||
| 22. Round | 03/04/2022 | USSA Vertou [Youth B] | - | Angers SCO [Youth B] | 0:1 | ||||
| 23. Round | 10/04/2022 | LB Châteauroux [Youth B] | - | Angers SCO [Youth B] | 1:3 | ||||
| 24. Round | 17/04/2022 | Angers SCO [Youth B] | - | SO Cholet [Youth B] | 5:2 | ||||
| 25. Round | 01/05/2022 | FC Lorient [Youth B] | - | Angers SCO [Youth B] | 0:3 |
France