| 1. Round | 22/08/2021 | EA Guingamp [Youth] | - | Le Mans FC [Youth] | 1:3 | ||||
| 4. Round | 12/09/2021 | Girondins Bordeaux [Youth] | - | EA Guingamp [Youth] | 2:1 | ||||
| 5. Round | 19/09/2021 | EA Guingamp [Youth] | - | FC Nantes [Youth] | 0:3 | ||||
| 6. Round | 25/09/2021 | Angers SCO [Youth] | - | EA Guingamp [Youth] | 0:3 | ||||
| 11. Round | 14/11/2021 | EA Guingamp [Youth] | - | Stade Rennais [Youth] | 1:0 | ||||
| 14. Round | 05/12/2021 | EA Guingamp [Youth] | - | SA Mérignac [Youth] | 5:2 | ||||
| 23. Round | 13/04/2022 | Stade Rennais [Youth] | - | EA Guingamp [Youth] | 1:2 | ||||
| 24. Round | 17/04/2022 | EA Guingamp [Youth] | - | Stade Brestois 29 [Youth] | 0:1 | ||||
| 26. Round | 15/05/2022 | Le Mans FC [Youth] | - | EA Guingamp [Youth] | 2:2 |
France