| 10. Round | 23/10/2021 | EA Guingamp B | - | AS Poissy | 1:1 | ||||
| 12. Round | 20/11/2021 | EA Guingamp B | - | Châteaubriant Voltigeurs | 2:3 | ||||
| 15. Round | 15/01/2022 | SO Romorantin | - | EA Guingamp B | 2:3 | ||||
| 16. Round | 22/01/2022 | EA Guingamp B | - | AS Vitré | 0:5 | ||||
| 13. Round | 26/01/2022 | Vannes OC | - | EA Guingamp B | 2:0 | ||||
| 18. Round | 12/02/2022 | EA Guingamp B | - | US Saint-Malo | 0:0 | ||||
| 20. Round | 05/03/2022 | EA Guingamp B | - | St-Pryvé St-Hilaire | 1:1 | ||||
| 21. Round | 12/03/2022 | Blois Foot 41 | - | EA Guingamp B | 5:2 | ||||
| 22. Round | 19/03/2022 | EA Guingamp B | - | FC Lorient B | 1:2 | ||||
| 29. Round | 21/05/2022 | EA Guingamp B | - | SO Romorantin | 1:2 |
France