| 1. Round | 05/09/2021 | CD Eldense | - | CF Intercity | 0:0 |  |
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| 2. Round | 12/09/2021 | CF Intercity | - | Hércules CF | 1:2 | |
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| 3. Round | 19/09/2021 | Real Murcia | - | CF Intercity | 2:0 | ||||
| 5. Round | 03/10/2021 | Águilas FC | - | CF Intercity | 1:2 | |
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| 7. Round | 17/10/2021 | CD Toledo | - | CF Intercity | 0:1 | ||||
| 8. Round | 24/10/2021 | CF Intercity | - | CD Marchamalo | 3:0 |  |
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| 9. Round | 31/10/2021 | Recreativo Granada | - | CF Intercity | 3:3 | ||||
| 10. Round | 07/11/2021 | CF Intercity | - | CS Puertollano CF | 4:0 | ||||
| 11. Round | 14/11/2021 | CF Intercity | - | Mar Menor CF | 3:0 | ||||
| 17. Round | 09/01/2022 | CF Intercity | - | CF La Nucía | 1:1 | ||||
| 18. Round | 23/01/2022 | CF Intercity | - | CD Eldense | 1:1 | |
Spain