| 1. Round | 23/07/1980 | Nîmes Olympique | - | FC Nantes | 2:3 |  |
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| 2. Round | 28/07/1980 | FC Nantes | - | Girondins Bordeaux | 1:0 | ||||
| 3. Round | 04/08/1980 | OGC Nice | - | FC Nantes | 3:2 | ||||
| 24. Round | 24/01/1981 | Olympique Lyonnais | - | FC Nantes | 0:0 | ||||
| 25. Round | 30/01/1981 | FC Nantes | - | SÉC Bastia | 2:1 | |
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| 26. Round | 07/02/1981 | Paris Saint-Germain | - | FC Nantes | 0:2 | |
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| 27. Round | 20/02/1981 | FC Nantes | - | Angers SCO | 3:1 | |
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| 28. Round | 26/02/1981 | Lille OSC | - | FC Nantes | 0:3 | |
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| 29. Round | 13/03/1981 | FC Nantes | - | RC Strasbourg | 1:1 | ||||
| 30. Round | 27/03/1981 | US Valenciennes-Anzin | - | FC Nantes | 3:3 | |
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| 31. Round | 06/04/1981 | FC Nantes | - | AJ Auxerre | 0:1 | ||||
| 35. Round | 11/05/1981 | FC Nantes | - | AS Saint-Étienne | 1:1 | ||||
| 36. Round | 21/05/1981 | FC Nantes | - | RC Lens | 2:0 | |
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| 37. Round | 28/05/1981 | FC Sochaux | - | FC Nantes | 2:4 | |
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| 38. Round | 01/06/1981 | FC Nantes | - | Nîmes Olympique | 1:1 |
France