| 6. Round | 10/10/2021 | CA Pulpileño | - | Hércules CF | 0:4 | ||||
| 7. Round | 17/10/2021 | Real Murcia | - | CA Pulpileño | 1:1 | ||||
| 8. Round | 24/10/2021 | CA Pulpileño | - | UD Melilla | 1:3 | ||||
| 9. Round | 31/10/2021 | Águilas FC | - | CA Pulpileño | 0:0 | ||||
| 22. Round | 09/03/2022 | CA Pulpileño | - | CD Eldense | 1:3 | ||||
| 25. Round | 13/03/2022 | UD Melilla | - | CA Pulpileño | 0:1 |  |
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| 26. Round | 20/03/2022 | CA Pulpileño | - | Águilas FC | 2:2 | ||||
| 27. Round | 27/03/2022 | Atlético Mancha Real | - | CA Pulpileño | 1:1 | ||||
| 34. Round | 15/05/2022 | CA Pulpileño | - | UD Socuéllamos | 1:2 | |
Spain