| 3. Round | 21/08/2021 | Vannes OC | - | US Granvillaise | 0:0 |  |
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| 4. Round | 28/08/2021 | SO Romorantin | - | Vannes OC | 1:2 | ||||
| 5. Round | 04/09/2021 | Vannes OC | - | FC Rouen 1899 | 1:2 | ||||
| 6. Round | 11/09/2021 | AS Vitré | - | Vannes OC | 0:1 | ||||
| 7. Round | 18/09/2021 | Vannes OC | - | FC Versailles | 0:1 | ||||
| 8. Round | 25/09/2021 | US Saint-Malo | - | Vannes OC | 2:2 | ||||
| 9. Round | 09/10/2021 | Vannes OC | - | Stade Plabennec | 1:1 | ||||
| 11. Round | 07/11/2021 | Vannes OC | - | Blois Foot 41 | 2:2 | ||||
| 12. Round | 20/11/2021 | FC Lorient B | - | Vannes OC | 1:0 | ||||
| 14. Round | 11/12/2021 | AS Poissy | - | Vannes OC | 1:3 | ||||
| 17. Round | 05/02/2022 | US Granvillaise | - | Vannes OC | 1:2 | ||||
| 18. Round | 12/02/2022 | Vannes OC | - | SO Romorantin | 3:1 | ||||
| 19. Round | 18/02/2022 | FC Rouen 1899 | - | Vannes OC | 0:2 | ||||
| 24. Round | 09/04/2022 | Vannes OC | - | St-Pryvé St-Hilaire | 3:3 | ||||
| 26. Round | 23/04/2022 | Vannes OC | - | FC Lorient B | 0:3 | ||||
| 28. Round | 14/05/2022 | Vannes OC | - | AS Poissy | 1:1 | ||||
| 29. Round | 21/05/2022 | C'Chartres Football | - | Vannes OC | 1:1 | ||||
| 30. Round | 28/05/2022 | Vannes OC | - | Châteaubriant Voltigeurs | 1:2 |
France