1. Round | 08/08/2021 | AS Saint-Étienne | - | FC Lorient | 1:1 | ||||
2. Round | 15/08/2021 | RC Lens | - | AS Saint-Étienne | 2:2 | ||||
3. Round | 21/08/2021 | AS Saint-Étienne | - | Lille OSC | 1:1 | ||||
4. Round | 28/08/2021 | Olympique Marseille | - | AS Saint-Étienne | 3:1 | ||||
5. Round | 12/09/2021 | Montpellier HSC | - | AS Saint-Étienne | 2:0 | ||||
6. Round | 18/09/2021 | AS Saint-Étienne | - | Girondins Bordeaux | 1:2 | ||||
7. Round | 22/09/2021 | AS Monaco | - | AS Saint-Étienne | 3:1 | ||||
9. Round | 03/10/2021 | AS Saint-Étienne | - | Olympique Lyon | 1:1 | ||||
10. Round | 17/10/2021 | RC Strasbourg | - | AS Saint-Étienne | 5:1 | ||||
12. Round | 30/10/2021 | FC Metz | - | AS Saint-Étienne | 1:1 | ||||
13. Round | 07/11/2021 | AS Saint-Étienne | - | Clermont Foot 63 | 3:2 | ||||
14. Round | 21/11/2021 | ESTAC Troyes | - | AS Saint-Étienne | 0:1 | ||||
15. Round | 28/11/2021 | AS Saint-Étienne | - | Paris Saint-Germain | 1:3 | ||||
17. Round | 05/12/2021 | AS Saint-Étienne | - | Stade Rennais | 0:5 | ||||
18. Round | 11/12/2021 | Stade Reims | - | AS Saint-Étienne | 2:0 |