| 13. Round | 22/01/2022 | Montpellier HSC [Women] | - | Olympique Lyonnais [Women] | 2:3 |  |
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| 14. Round | 06/02/2022 | Olympique Lyonnais [Women] | - | Girondins Bordeaux [Women] | 1:0 |  |
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| 15. Round | 27/02/2022 | Stade de Reims [Women] | - | Olympique Lyonnais [Women] | 0:2 | ||||
| 16. Round | 12/03/2022 | AS Saint-Étienne [Women] | - | Olympique Lyonnais [Women] | 1:1 | ||||
| 19. Round | 17/04/2022 | FC Fleury 91 [Women] | - | Olympique Lyonnais [Women] | 1:2 | ||||
| 21. Round | 29/05/2022 | Paris Saint-Germain [Women] | - | Olympique Lyonnais [Women] | 0:1 | ||||
| 22. Round | 01/06/2022 | Olympique Lyonnais [Women] | - | GPSO 92 Issy [Women] | 4:0 | |
France