| 3. Round | 12/09/2021 | Paris 13 Atletico [Youth B] | - | Lille OSC [Youth B] | 0:1 | ||||
| 4. Round | 19/09/2021 | Lille OSC [Youth B] | - | JA Drancy [Youth B] | 2:0 |  |
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| 5. Round | 25/09/2021 | ESTAC Troyes [Youth B] | - | Lille OSC [Youth B] | 0:1 | ||||
| 6. Round | 03/10/2021 | Lille OSC [Youth B] | - | AC Boulogne-Billancourt [Youth B] | 4:0 | ||||
| 7. Round | 10/10/2021 | Amiens SC [Youth B] | - | Lille OSC [Youth B] | 3:2 | ||||
| 8. Round | 17/10/2021 | Lille OSC [Youth B] | - | US Boulogne [Youth B] | 4:0 | ||||
| 9. Round | 23/10/2021 | Valenciennes FC [Youth B] | - | Lille OSC [Youth B] | 1:1 |
France
Madagascar