| 1. Round | 28/08/2021 | FC Istres [Youth B] | - | AS Muret [Youth B] | 2:0 | ||||
| 2. Round | 05/09/2021 | AS Muret [Youth B] | - | Marignane Gignac [Youth B] | 3:4 | ||||
| 3. Round | 12/09/2021 | SA Mérignac [Youth B] | - | AS Muret [Youth B] | 2:0 | ||||
| 4. Round | 19/09/2021 | AS Béziers [Youth B] | - | AS Muret [Youth B] | 3:1 | ||||
| 7. Round | 09/10/2021 | AS Muret [Youth B] | - | Montpellier HSC [Youth B] | 1:4 | ||||
| 9. Round | 24/10/2021 | AS Muret [Youth B] | - | Girondins Bordeaux [Youth B] | 0:1 | ||||
| 14. Round | 30/01/2022 | Marignane Gignac [Youth B] | - | AS Muret [Youth B] | 1:0 | ||||
| 16. Round | 06/02/2022 | AS Muret [Youth B] | - | AS Béziers [Youth B] | 1:1 | ||||
| 17. Round | 12/02/2022 | AC Vedène [Youth B] | - | AS Muret [Youth B] | 4:4 |
France