| 2. Round | 29/08/2021 | SA Mérignac [Youth] | - | EA Guingamp [Youth] | 0:3 | ||||
| 7. Round | 03/10/2021 | EA Guingamp [Youth] | - | LB Châteauroux [Youth] | 2:1 | ||||
| 8. Round | 09/10/2021 | US Avranches [Youth] | - | EA Guingamp [Youth] | 0:2 | ||||
| 9. Round | 17/10/2021 | EA Guingamp [Youth] | - | US Concarneau [Youth] | 0:0 | ||||
| 10. Round | 24/10/2021 | Stade Lavallois [Youth] | - | EA Guingamp [Youth] | 0:1 | ||||
| 12. Round | 21/11/2021 | Stade Brestois 29 [Youth] | - | EA Guingamp [Youth] | 3:0 | ||||
| 15. Round | 16/01/2022 | USSA Vertou [Youth] | - | EA Guingamp [Youth] | 1:0 | ||||
| 21. Round | 13/02/2022 | EA Guingamp [Youth] | - | Angers SCO [Youth] | 0:2 | ||||
| 25. Round | 01/05/2022 | EA Guingamp [Youth] | - | Tours FC [Youth] | 4:0 |
France