| 17. Round | 05/02/2022 | FC Versailles | - | EA Guingamp B | 1:1 | ||||
| 19. Round | 19/02/2022 | Stade Plabennec | - | EA Guingamp B | 1:0 | ||||
| 23. Round | 26/03/2022 | SM Caen B | - | EA Guingamp B | 0:2 | ||||
| 24. Round | 09/04/2022 | AS Poissy | - | EA Guingamp B | 1:1 | ||||
| 25. Round | 16/04/2022 | EA Guingamp B | - | C'Chartres Football | 3:4 | ||||
| 28. Round | 14/05/2022 | US Granvillaise | - | EA Guingamp B | 3:4 | ||||
| 30. Round | 28/05/2022 | FC Rouen 1899 | - | EA Guingamp B | 2:1 |
France