1. Round | 28/08/2021 | PEC Zwolle [U21] | - | De Graafschap [U21] | 2:1 | ||||
2. Round | 11/09/2021 | De Graafschap [U21] | - | SBV Excelsior [U21] | 0:1 | ||||
3. Round | 18/09/2021 | Roda JC Kerkrade [U21] | - | De Graafschap [U21] | 3:3 | ||||
4. Round | 25/09/2021 | De Graafschap [U21] | - | FC Emmen [U21] | 1:1 | ||||
5. Round | 02/10/2021 | Vitesse [U21] | - | De Graafschap [U21] | 1:1 | ||||
6. Round | 16/10/2021 | Willem II [U21] | - | De Graafschap [U21] | 1:2 | ||||
7. Round | 23/10/2021 | De Graafschap [U21] | - | Alphense Boys [U21] | 2:1 | ||||
8. Round | 30/10/2021 | De Graafschap [U21] | - | Vitesse [U21] | 6:0 | ||||
10. Round | 20/11/2021 | De Graafschap [U21] | - | Roda JC Kerkrade [U21] | 3:1 | ||||
12. Round | 05/02/2022 | De Graafschap [U21] | - | PEC Zwolle [U21] | 0:1 | ||||
13. Round | 12/02/2022 | Alphense Boys [U21] | - | De Graafschap [U21] | 1:3 |