| 9. Round | 08/09/1980 | Angers SCO | - | FC Nantes | 0:3 | ||||
| 10. Round | 11/09/1980 | FC Nantes | - | Lille OSC | 4:1 |  |
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| 13. Round | 04/10/1980 | AJ Auxerre | - | FC Nantes | 0:0 | ||||
| 14. Round | 14/10/1980 | FC Nantes | - | FC Metz | 1:0 | ||||
| 15. Round | 17/10/1980 | AS Monaco | - | FC Nantes | 2:1 | ||||
| 16. Round | 30/10/1980 | FC Nantes | - | Stade Lavallois | 4:1 | ||||
| 17. Round | 07/11/1980 | AS Saint-Étienne | - | FC Nantes | 0:0 | ||||
| 18. Round | 11/11/1980 | RC Lens | - | FC Nantes | 0:0 | ||||
| 20. Round | 28/11/1980 | Girondins Bordeaux | - | FC Nantes | 0:0 | ||||
| 26. Round | 07/02/1981 | Paris Saint-Germain | - | FC Nantes | 0:2 |
France