| 2. Round | 15/02/2022 | Rosario Central II | - | Vélez Sarsfield II | 1:1 | ||||
| 5. Round | 05/03/2022 | Vélez Sarsfield II | - | Estudiantes II | 0:2 | ||||
| 6. Round | 13/03/2022 | Arsenal de Sarandí II | - | Vélez Sarsfield II | 1:0 | ||||
| 7. Round | 20/03/2022 | Argentinos Juniors II | - | Vélez Sarsfield II | 3:3 | ||||
| 9. Round | 08/04/2022 | Vélez Sarsfield II | - | Boca Juniors II | 2:3 |  |
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| 10. Round | 13/04/2022 | Godoy Cruz II | - | Vélez Sarsfield II | 1:0 | ||||
| 13. Round | 29/04/2022 | Vélez Sarsfield II | - | Tigre II | 4:2 |
Argentina