| 23. Round | 05/02/2022 | AS Saint-Étienne | - | Montpellier HSC | 3:1 | ||||
| 24. Round | 13/02/2022 | Clermont Foot 63 | - | AS Saint-Étienne | 1:2 | ||||
| 25. Round | 20/02/2022 | AS Saint-Étienne | - | RC Strasbourg | 2:2 | ||||
| 26. Round | 26/02/2022 | Paris Saint-Germain | - | AS Saint-Étienne | 3:1 | ||||
| 27. Round | 06/03/2022 | AS Saint-Étienne | - | FC Metz | 1:0 | ||||
| 28. Round | 11/03/2022 | Lille OSC | - | AS Saint-Étienne | 0:0 | ||||
| 29. Round | 18/03/2022 | AS Saint-Étienne | - | ESTAC Troyes | 1:1 | ||||
| 37. Round | 14/05/2022 | AS Saint-Étienne | - | Stade de Reims | 1:2 | ||||
| 38. Round | 21/05/2022 | FC Nantes | - | AS Saint-Étienne | 1:1 |
Mali