| 1. Round | 02/07/2022 | Mazatlán FC | - | Puebla FC | 2:4 | ||||
| 2. Round | 09/07/2022 | Puebla FC | - | Santos Laguna | 1:0 |  |
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| 3. Round | 16/07/2022 | Puebla FC | - | Club León | 1:1 | ||||
| 4. Round | 24/07/2022 | Cruz Azul | - | Puebla FC | 2:2 | ||||
| 5. Round | 27/07/2022 | CF Monterrey | - | Puebla FC | 1:0 | ||||
| 6. Round | 31/07/2022 | Puebla FC | - | Atlético San Luis | 0:0 | ||||
| 16. Round | 03/08/2022 | Deportivo Toluca | - | Puebla FC | 1:1 | ||||
| 8. Round | 13/08/2022 | Club Tijuana | - | Puebla FC | 3:3 | ||||
| 9. Round | 17/08/2022 | Puebla FC | - | Club Necaxa | 2:2 | ||||
| 10. Round | 21/08/2022 | Atlas Guadalajara | - | Puebla FC | 1:1 | ||||
| 11. Round | 27/08/2022 | Puebla FC | - | FC Juárez | 2:2 | ||||
| 12. Round | 02/09/2022 | Gallos Blancos | - | Puebla FC | 1:1 | ||||
| 13. Round | 08/09/2022 | Puebla FC | - | CF Pachuca | 2:2 | ||||
| 14. Round | 11/09/2022 | Deportivo Guadalajara | - | Puebla FC | 1:0 | |
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| 15. Round | 17/09/2022 | Puebla FC | - | UANL Tigres | 2:1 | ||||
| 7. Round | 24/09/2022 | Puebla FC | - | Pumas UNAM | 2:1 | |
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| 17. Round | 01/10/2022 | Puebla FC | - | CF América | 1:2 |
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