| 4. Round | 29/07/2022 | Guaireña FC | - | General Caballero DJLM | 1:2 |  |
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| 7. Round | 20/08/2022 | General Caballero DJLM | - | Club Olimpia | 0:2 | ||||
| 8. Round | 27/08/2022 | General Caballero DJLM | - | Cerro Porteño | 1:1 | ||||
| 9. Round | 03/09/2022 | Resistencia SC | - | General Caballero DJLM | 0:0 | |
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| 10. Round | 13/09/2022 | General Caballero DJLM | - | 12 de Octubre de Itauguá | 2:1 | ||||
| 15. Round | 05/10/2022 | General Caballero DJLM | - | Guaireña FC | 0:0 | ||||
| 17. Round | 15/10/2022 | General Caballero DJLM | - | Sportivo Ameliano | 2:0 | ||||
| 18. Round | 22/10/2022 | Club Olimpia | - | General Caballero DJLM | 2:1 | ||||
| 19. Round | 28/10/2022 | Cerro Porteño | - | General Caballero DJLM | 2:1 |
Argentina
Croatia